Increased erythrocyte 2,3-DPG: Usefulness during hypoxia
Ten hypoxic patients were randomly treated with either intravenous saline or intravenous inosine, pyruvate, and inorganic phosphate (IPP). IPP proved to be an easy, nontoxic method of rapidly increasing erythrocyte 2,3-DPG. There was no evidence of improved tissue oxygenation in association with inc...
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| Veröffentlicht in: | The Journal of surgical research 1974-06, Vol.16 (6), p.569-574 |
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| container_title | The Journal of surgical research |
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| creator | Proctor, H.J. Fry, James |
| description | Ten hypoxic patients were randomly treated with either intravenous saline or intravenous inosine, pyruvate, and inorganic phosphate (IPP). IPP proved to be an easy, nontoxic method of rapidly increasing erythrocyte 2,3-DPG. There was no evidence of improved tissue oxygenation in association with increased concentrations or erythrocyte 2,3-DPG. Several alternative interpretations of the data are presented. |
| doi_str_mv | 10.1016/0022-4804(74)90087-0 |
| format | Article |
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IPP proved to be an easy, nontoxic method of rapidly increasing erythrocyte 2,3-DPG. There was no evidence of improved tissue oxygenation in association with increased concentrations or erythrocyte 2,3-DPG. Several alternative interpretations of the data are presented.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/0022-4804(74)90087-0</identifier><identifier>PMID: 4601308</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Calcium - blood ; Carbon Dioxide - blood ; Cardiac Output ; Diphosphoglyceric Acids - analysis ; Diphosphoglyceric Acids - blood ; Erythrocytes - analysis ; Erythrocytes - metabolism ; Female ; Hemoglobins - analysis ; Humans ; Hydrogen-Ion Concentration ; Hypoxia - blood ; Injections, Intravenous ; Inosine - administration & dosage ; Inosine - metabolism ; Lactates - blood ; Male ; Middle Aged ; Oxygen - blood ; Oxygen Consumption ; Phosphates - administration & dosage ; Phosphates - metabolism ; Positive-Pressure Respiration ; Pyruvates - administration & dosage ; Pyruvates - metabolism ; Space life sciences</subject><ispartof>The Journal of surgical research, 1974-06, Vol.16 (6), p.569-574</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c2996d0f742842ce1871bd66d832563f2898d40b244dcd455298d2dd0d36ff983</citedby><cites>FETCH-LOGICAL-c357t-c2996d0f742842ce1871bd66d832563f2898d40b244dcd455298d2dd0d36ff983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022480474900870$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4601308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Proctor, H.J.</creatorcontrib><creatorcontrib>Fry, James</creatorcontrib><title>Increased erythrocyte 2,3-DPG: Usefulness during hypoxia</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Ten hypoxic patients were randomly treated with either intravenous saline or intravenous inosine, pyruvate, and inorganic phosphate (IPP). 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| ispartof | The Journal of surgical research, 1974-06, Vol.16 (6), p.569-574 |
| issn | 0022-4804 1095-8673 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Calcium - blood Carbon Dioxide - blood Cardiac Output Diphosphoglyceric Acids - analysis Diphosphoglyceric Acids - blood Erythrocytes - analysis Erythrocytes - metabolism Female Hemoglobins - analysis Humans Hydrogen-Ion Concentration Hypoxia - blood Injections, Intravenous Inosine - administration & dosage Inosine - metabolism Lactates - blood Male Middle Aged Oxygen - blood Oxygen Consumption Phosphates - administration & dosage Phosphates - metabolism Positive-Pressure Respiration Pyruvates - administration & dosage Pyruvates - metabolism Space life sciences |
| title | Increased erythrocyte 2,3-DPG: Usefulness during hypoxia |
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