Increased erythrocyte 2,3-DPG: Usefulness during hypoxia

Ten hypoxic patients were randomly treated with either intravenous saline or intravenous inosine, pyruvate, and inorganic phosphate (IPP). IPP proved to be an easy, nontoxic method of rapidly increasing erythrocyte 2,3-DPG. There was no evidence of improved tissue oxygenation in association with inc...

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Veröffentlicht in:	The Journal of surgical research 1974-06, Vol.16 (6), p.569-574
Hauptverfasser:	Proctor, H.J., Fry, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Calcium - blood Carbon Dioxide - blood Cardiac Output Diphosphoglyceric Acids - analysis Diphosphoglyceric Acids - blood Erythrocytes - analysis Erythrocytes - metabolism Female Hemoglobins - analysis Humans Hydrogen-Ion Concentration Hypoxia - blood Injections, Intravenous Inosine - administration & dosage Inosine - metabolism Lactates - blood Male Middle Aged Oxygen - blood Oxygen Consumption Phosphates - administration & dosage Phosphates - metabolism Positive-Pressure Respiration Pyruvates - administration & dosage Pyruvates - metabolism Space life sciences
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Zusammenfassung:	Ten hypoxic patients were randomly treated with either intravenous saline or intravenous inosine, pyruvate, and inorganic phosphate (IPP). IPP proved to be an easy, nontoxic method of rapidly increasing erythrocyte 2,3-DPG. There was no evidence of improved tissue oxygenation in association with increased concentrations or erythrocyte 2,3-DPG. Several alternative interpretations of the data are presented.
ISSN:	0022-4804 1095-8673
DOI:	10.1016/0022-4804(74)90087-0