Topochemical Decomposition Patterns of Aspirin
Aspirin in alkaline environment in a solid dosage form is shown to decompose by topochemical reaction patterns. At lower temperatures, the rate-determining step is diffusion controlled, whereas at higher temperatures it is kinetically controlled.
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.755-757 |
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| container_end_page | 757 |
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| container_issue | 5 |
| container_start_page | 755 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 63 |
| creator | Nelson, Elwyn Eppich, David Carstensen, J.T. |
| description | Aspirin in alkaline environment in a solid dosage form is shown to decompose by topochemical reaction patterns. At lower temperatures, the rate-determining step is diffusion controlled, whereas at higher temperatures it is kinetically controlled. |
| doi_str_mv | 10.1002/jps.2600630522 |
| format | Article |
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Pharm. Sci</addtitle><description>Aspirin in alkaline environment in a solid dosage form is shown to decompose by topochemical reaction patterns. At lower temperatures, the rate-determining step is diffusion controlled, whereas at higher temperatures it is kinetically controlled.</description><subject>Alkalies</subject><subject>Aspirin</subject><subject>Aspirin-degradation in alkaline media</subject><subject>aspirin-in alkaline media</subject><subject>Aspirin—degradation in alkaline media, topochemical reactions</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Degradation</subject><subject>Degradation, aspirin—in alkaline media, topochemical reactions</subject><subject>Diffusion</subject><subject>Drug Storage</subject><subject>Kinetics</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Temperature</subject><subject>topochemical reactions</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EKqWwsiF1YktwHDuJR1SgfFR8iKKOluNchCGJg50C_fcYpSpiQEw33PO-unsQOoxwGGFMTl5aF5IE4yTGjJAtNIwYwUGCo3QbDT1AgphRvov2nHvBHsOMDdCAZoRzng1RODetUc9QayWr8RkoU7fG6U6bZnwvuw5s48amHJ-6Vlvd7KOdUlYODtZzhJ4uzueTy2B2N72anM4CRUlKAqCJjIAXaaZIIQuIKE-Aq5xyxgoi45JQLvNc-isyAKKKvASlYsnSjCiaJ_EIHfe9rTVvS3CdqLVTUFWyAbN0IiMUx5xhD4Y9qKxxzkIpWqtraVciwuJbkPCCxI8gHzhaNy_zGooNvjbi97zff-gKVv-0iev7x1_dQZ_VroPPTVbaV5GkccrE4nYqJo83U7w4m4oHz2c9D17luwYrnNLQKCi0BdWJwui_3vgC3FSUAA</recordid><startdate>197405</startdate><enddate>197405</enddate><creator>Nelson, Elwyn</creator><creator>Eppich, David</creator><creator>Carstensen, J.T.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197405</creationdate><title>Topochemical Decomposition Patterns of Aspirin</title><author>Nelson, Elwyn ; Eppich, David ; Carstensen, J.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4272-e46a1e9d78c2dade1496e9cb4955d2a3f249abba8298ee2cdbfecc3a5782c4b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Alkalies</topic><topic>Aspirin</topic><topic>Aspirin-degradation in alkaline media</topic><topic>aspirin-in alkaline media</topic><topic>Aspirin—degradation in alkaline media, topochemical reactions</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Degradation</topic><topic>Degradation, aspirin—in alkaline media, topochemical reactions</topic><topic>Diffusion</topic><topic>Drug Storage</topic><topic>Kinetics</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Temperature</topic><topic>topochemical reactions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nelson, Elwyn</creatorcontrib><creatorcontrib>Eppich, David</creatorcontrib><creatorcontrib>Carstensen, J.T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nelson, Elwyn</au><au>Eppich, David</au><au>Carstensen, J.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topochemical Decomposition Patterns of Aspirin</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1974-05, Vol.63 (5), p.755-757 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Alkalies Aspirin Aspirin-degradation in alkaline media aspirin-in alkaline media Aspirin—degradation in alkaline media, topochemical reactions Chemical Phenomena Chemistry Chemistry, Pharmaceutical Degradation Degradation, aspirin—in alkaline media, topochemical reactions Diffusion Drug Storage Kinetics Spectrophotometry, Ultraviolet Temperature topochemical reactions |
| title | Topochemical Decomposition Patterns of Aspirin |
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