Topochemical Decomposition Patterns of Aspirin

Aspirin in alkaline environment in a solid dosage form is shown to decompose by topochemical reaction patterns. At lower temperatures, the rate-determining step is diffusion controlled, whereas at higher temperatures it is kinetically controlled.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.755-757
Hauptverfasser:	Nelson, Elwyn, Eppich, David, Carstensen, J.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkalies Aspirin Aspirin-degradation in alkaline media aspirin-in alkaline media Aspirin—degradation in alkaline media, topochemical reactions Chemical Phenomena Chemistry Chemistry, Pharmaceutical Degradation Degradation, aspirin—in alkaline media, topochemical reactions Diffusion Drug Storage Kinetics Spectrophotometry, Ultraviolet Temperature topochemical reactions
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Beschreibung
Zusammenfassung:	Aspirin in alkaline environment in a solid dosage form is shown to decompose by topochemical reaction patterns. At lower temperatures, the rate-determining step is diffusion controlled, whereas at higher temperatures it is kinetically controlled.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600630522