The effect of scopolamine on the amnesia induced by electroconvulsive shock

The effect of scopolamine on the amnesia induced by electroconvulsive shock

Rats previously allowed to drink water from a spout received a mouth-shock at the spout as one-trial avoidance training. In animals where a pair of ECSs followed the mouth-shock, a retention test 48 hr later revealed a reliable amnesia relative to sham ECS animals. When scopolamine was injected 30 m...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1974-05, Vol.2 (3), p.443-446
Hauptverfasser: Albert, D.J., Mah, C.J., Bose, W.B.
Format: Artikel
Sprache:eng
Schlagworte:
Amnesia
Amnesia - physiopathology
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Cholinergic
Electroconvulsive shock
Electrodes
Electroshock
Humans
Male
Memory
Memory - drug effects
Mouth
Rats
Reaction Time - drug effects
Scopolamine
Scopolamine - pharmacology
Time Factors
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Beschreibung
Zusammenfassung:Rats previously allowed to drink water from a spout received a mouth-shock at the spout as one-trial avoidance training. In animals where a pair of ECSs followed the mouth-shock, a retention test 48 hr later revealed a reliable amnesia relative to sham ECS animals. When scopolamine was injected 30 min prior to the test trials, the amnesia was unchanged. The present results do not confirm previous suggestions that scopolamine can completely reverse ECS-induced amnesia.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(74)90096-3