Effects of Vitamin E on the Aggregation and the Lipid Peroxidation of Platelets Exposed to Hydrogen Peroxide

Effects of Vitamin E on the Aggregation and the Lipid Peroxidation of Platelets Exposed to Hydrogen Peroxide

The hydrogen peroxide (H2O2)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggregation could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed...

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Veröffentlicht in:The Tohoku Journal of Experimental Medicine 1974, Vol.112(3), pp.271-278
Hauptverfasser: HIGASHI, OTOTAKA, KIKUCHI, YOKO
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Adenosine Diphosphate - antagonists & inhibitors
Adenosine Diphosphate - pharmacology
Blood Platelets - drug effects
Blood Platelets - metabolism
Dextrans - pharmacology
hydrogen peroxide
Hydrogen Peroxide - antagonists & inhibitors
Lipid Metabolism
lipid peroxidation
Nicotinic Acids
Oxidation-Reduction
Platelet Adhesiveness - drug effects
platelet aggregation
Sodium Chloride - pharmacology
Sucrose - pharmacology
thrombosis
Vitamin E - pharmacology
vitamin E-nicotinate
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Zusammenfassung:The hydrogen peroxide (H2O2)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggregation could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed to H2O2 could also be inhibited by vitamin E-nicotinate. The lipid peroxide formation associated with membrane disruption may be involved in the mechanism underlying the H2O2-induced platelet aggregation.
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.112.271