Molecular Structural Factors in Competitive Inhibition of Sugar Transport

The high potency of phloretin as a competitive inhibitor of the human red cell's monosaccharide transport system is not shared by any of several molecular fragments of phloretin, but is duplicated in certain artificial estrogens resembling phloretin in respect to the spacing between terminal ph...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1959-07, Vol.130 (3367), p.104-105
1. Verfasser:	LeFevre, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atmospheric chemistry Biological Transport BIOLOGY AND MEDICINE CHEMICAL REACTIONS CONFIGURATION DRUGS ERYTHROCYTES Erythrocytes - metabolism ESTROGENS HORMONES Humans MAN METABOLISM MOLECULES Monosaccharides - blood Old Medline Ozone PHENOLS Propiophenones - pharmacology Public health SACCHARIDES STEROIDS SUGARS Weather Wind velocity
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Beschreibung
Zusammenfassung:	The high potency of phloretin as a competitive inhibitor of the human red cell's monosaccharide transport system is not shared by any of several molecular fragments of phloretin, but is duplicated in certain artificial estrogens resembling phloretin in respect to the spacing between terminal phenolic --OH groups. Related molecules which are slightly less extendible are comparatively inactive.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.130.3367.104