The Influence of Thymidine on the Blastoid Transformation of Human Lymphocytes

The Influence of Thymidine on the Blastoid Transformation of Human Lymphocytes

Summary The percentage of human lymphocytes undergoing blastoid transformation induced by PHA was significantly increased by the presence of thymidine at concentrations between 0.02 mM and 0.2 mM. Concentrations under 0.002 mM were ineffective, whereas concentrations between 2 and 20 mM inhibited th...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1974-03, Vol.145 (3), p.958-959
Hauptverfasser: Diddi, Manuel Gonzalez, Lonngi, Gustavo, Gonzalez, Clicerio R., Gallegos, Alfredo J.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Lectins - antagonists & inhibitors
Lymphocyte Activation - drug effects
Stimulation, Chemical
Thymidine - pharmacology
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Zusammenfassung:Summary The percentage of human lymphocytes undergoing blastoid transformation induced by PHA was significantly increased by the presence of thymidine at concentrations between 0.02 mM and 0.2 mM. Concentrations under 0.002 mM were ineffective, whereas concentrations between 2 and 20 mM inhibited the blastogenic effect of PHA. Maximal inhibition was obtained with 8 mM of the nucleoside.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-145-37932