Solubility relationships of drugs and their metabolites

Solubility relationships of drugs and their metabolites

The author shares a model experiment which should show the general way in which metabolism changes solubility and hence the penetration of the material into lipid tissue. These model systems should allow us to compare solubility relationships of the original material and its metabolite and predict t...

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Veröffentlicht in:Journal of chemical education 1974-04, Vol.51 (4), p.272-273
1. Verfasser: Goldsmith, Robert H
Format: Artikel
Sprache:eng
Schlagworte:
Benzoates - metabolism
Chemistry - education
Gentisates - metabolism
Hippurates - metabolism
Humans
Pharmaceutical Preparations - metabolism
Salicylates - metabolism
Solubility
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Zusammenfassung:The author shares a model experiment which should show the general way in which metabolism changes solubility and hence the penetration of the material into lipid tissue. These model systems should allow us to compare solubility relationships of the original material and its metabolite and predict the general effect of drug metabolism.
ISSN:0021-9584
1938-1328
DOI:10.1021/ed051p272