Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms
Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruc...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.751-754 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Digenis, G.A. Amos, H.E. Mitchell, G.E. Swintosky, J.V. Yang, K. Schelling, G.T. Parish, R.C. |
| description | Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruction as indicated by specific GLC analysis for the compounds. Two esters, methyl γ-methylmercapto-α-hydroxybutyrate and phenyl γ-methylmercapto-α-hydroxybutyrate, were found to be extensively destroyed upon incubation with rumen microorganisms. |
| doi_str_mv | 10.1002/jps.2600630521 |
| format | Article |
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Two esters, methyl γ-methylmercapto-α-hydroxybutyrate and phenyl γ-methylmercapto-α-hydroxybutyrate, were found to be extensively destroyed upon incubation with rumen microorganisms.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600630521</identifier><identifier>PMID: 4857321</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Cattle ; Chromatography, Gas ; Drug Stability ; effect of rumen microbial amino acid deamination ; Fermentation ; Hydroxybutyrates - metabolism ; Hydroxymethionine derivatives-synthesis ; Hydroxymethionine derivatives—synthesis, tested for resistance to in vitro destruction by rumen microorganisms ; in vitro incubation with rumen microorganisms ; Methionine - metabolism ; Methionine substitutes-ruminant nutrition ; Methionine substitutes—ruminant nutrition, stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms ; Nutrition ; Nutrition, ruminant—stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms, effect of rumen microbial amino acid deamination ; Rumen - microbiology ; ruminant-stability of nonnitrogenous compounds compared to methionine ; stability of nonnitrogenous compounds compared to methionine ; Sulfhydryl Compounds - metabolism ; tested for resistance to in vitro destruction by rumen microorganisms</subject><ispartof>Journal of pharmaceutical sciences, 1974-05, Vol.63 (5), p.751-754</ispartof><rights>1974 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1974 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3421-8dfd7ce11d367b0d5de1e64c328d744dfa2e2eba8e7605f106b96b353f1dcbba3</citedby><cites>FETCH-LOGICAL-c3421-8dfd7ce11d367b0d5de1e64c328d744dfa2e2eba8e7605f106b96b353f1dcbba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600630521$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600630521$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4857321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Digenis, G.A.</creatorcontrib><creatorcontrib>Amos, H.E.</creatorcontrib><creatorcontrib>Mitchell, G.E.</creatorcontrib><creatorcontrib>Swintosky, J.V.</creatorcontrib><creatorcontrib>Yang, K.</creatorcontrib><creatorcontrib>Schelling, G.T.</creatorcontrib><creatorcontrib>Parish, R.C.</creatorcontrib><title>Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruction as indicated by specific GLC analysis for the compounds. Two esters, methyl γ-methylmercapto-α-hydroxybutyrate and phenyl γ-methylmercapto-α-hydroxybutyrate, were found to be extensively destroyed upon incubation with rumen microorganisms.</description><subject>Animals</subject><subject>Cattle</subject><subject>Chromatography, Gas</subject><subject>Drug Stability</subject><subject>effect of rumen microbial amino acid deamination</subject><subject>Fermentation</subject><subject>Hydroxybutyrates - metabolism</subject><subject>Hydroxymethionine derivatives-synthesis</subject><subject>Hydroxymethionine derivatives—synthesis, tested for resistance to in vitro destruction by rumen microorganisms</subject><subject>in vitro incubation with rumen microorganisms</subject><subject>Methionine - metabolism</subject><subject>Methionine substitutes-ruminant nutrition</subject><subject>Methionine substitutes—ruminant nutrition, stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms</subject><subject>Nutrition</subject><subject>Nutrition, ruminant—stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms, effect of rumen microbial amino acid deamination</subject><subject>Rumen - microbiology</subject><subject>ruminant-stability of nonnitrogenous compounds compared to methionine</subject><subject>stability of nonnitrogenous compounds compared to methionine</subject><subject>Sulfhydryl Compounds - metabolism</subject><subject>tested for resistance to in vitro destruction by rumen microorganisms</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhUeIqoTClh2SV-wm-DGvsEPpg6A2QAOFneUZ30lvmbGD7aHk5_BP6zBRgQViZUv3O-c-TpI8Y3TKKOUvbzZ-ygtKC0Fzzh4kE5ZzmhaUlQ-TSQR4KvJs9ih57P0NjRjN88PkMKvyUnA2SX5eQLhGa9AAWQ21DxiGAJ6gIZdDj0aZQJZDcBgiRBaLV2QVVI0dhi2xLVlaYzA4uwZjB0_mtt_YwWhPLqFTATQJlvzRQQ8OzZosDLnaqeKnGWr1y_oWw_WuJRhygY2z1q2VQd_7J8lBqzoPT_fvUfLp9OTj_E16_u5sMX99njYi4yytdKvLBhjToihrqnMNDIqsEbzSZZbpVnHgUKsKyniDltGinhW1yEXLdFPXShwlL0bfjbPfBvBB9ugb6DplIO4mKy5KwbI8gtMRjFN676CVG4e9clvJqNxlImMm8ncmUfB87zzUPeh7fB9CrM_G-i12sP2Pm3z7fvWXdzpq0Qf4ca9V7qssSlHm8vPyTH44vioYPf4iTyNfjTzEU35HcNI3CKYBjQ6aILXFf61xB7AHvtA</recordid><startdate>197405</startdate><enddate>197405</enddate><creator>Digenis, G.A.</creator><creator>Amos, H.E.</creator><creator>Mitchell, G.E.</creator><creator>Swintosky, J.V.</creator><creator>Yang, K.</creator><creator>Schelling, G.T.</creator><creator>Parish, R.C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197405</creationdate><title>Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms</title><author>Digenis, G.A. ; Amos, H.E. ; Mitchell, G.E. ; Swintosky, J.V. ; Yang, K. ; Schelling, G.T. ; Parish, R.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3421-8dfd7ce11d367b0d5de1e64c328d744dfa2e2eba8e7605f106b96b353f1dcbba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Chromatography, Gas</topic><topic>Drug Stability</topic><topic>effect of rumen microbial amino acid deamination</topic><topic>Fermentation</topic><topic>Hydroxybutyrates - metabolism</topic><topic>Hydroxymethionine derivatives-synthesis</topic><topic>Hydroxymethionine derivatives—synthesis, tested for resistance to in vitro destruction by rumen microorganisms</topic><topic>in vitro incubation with rumen microorganisms</topic><topic>Methionine - metabolism</topic><topic>Methionine substitutes-ruminant nutrition</topic><topic>Methionine substitutes—ruminant nutrition, stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms</topic><topic>Nutrition</topic><topic>Nutrition, ruminant—stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms, effect of rumen microbial amino acid deamination</topic><topic>Rumen - microbiology</topic><topic>ruminant-stability of nonnitrogenous compounds compared to methionine</topic><topic>stability of nonnitrogenous compounds compared to methionine</topic><topic>Sulfhydryl Compounds - metabolism</topic><topic>tested for resistance to in vitro destruction by rumen microorganisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Digenis, G.A.</creatorcontrib><creatorcontrib>Amos, H.E.</creatorcontrib><creatorcontrib>Mitchell, G.E.</creatorcontrib><creatorcontrib>Swintosky, J.V.</creatorcontrib><creatorcontrib>Yang, K.</creatorcontrib><creatorcontrib>Schelling, G.T.</creatorcontrib><creatorcontrib>Parish, R.C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Digenis, G.A.</au><au>Amos, H.E.</au><au>Mitchell, G.E.</au><au>Swintosky, J.V.</au><au>Yang, K.</au><au>Schelling, G.T.</au><au>Parish, R.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1974-05</date><risdate>1974</risdate><volume>63</volume><issue>5</issue><spage>751</spage><epage>754</epage><pages>751-754</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruction as indicated by specific GLC analysis for the compounds. Two esters, methyl γ-methylmercapto-α-hydroxybutyrate and phenyl γ-methylmercapto-α-hydroxybutyrate, were found to be extensively destroyed upon incubation with rumen microorganisms.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4857321</pmid><doi>10.1002/jps.2600630521</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1974-05, Vol.63 (5), p.751-754 |
| issn | 0022-3549 1520-6017 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Cattle Chromatography, Gas Drug Stability effect of rumen microbial amino acid deamination Fermentation Hydroxybutyrates - metabolism Hydroxymethionine derivatives-synthesis Hydroxymethionine derivatives—synthesis, tested for resistance to in vitro destruction by rumen microorganisms in vitro incubation with rumen microorganisms Methionine - metabolism Methionine substitutes-ruminant nutrition Methionine substitutes—ruminant nutrition, stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms Nutrition Nutrition, ruminant—stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms, effect of rumen microbial amino acid deamination Rumen - microbiology ruminant-stability of nonnitrogenous compounds compared to methionine stability of nonnitrogenous compounds compared to methionine Sulfhydryl Compounds - metabolism tested for resistance to in vitro destruction by rumen microorganisms |
| title | Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms |
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