Methionine Substitutes in Ruminant Nutrition II: Stability of Nonnitrogenous Compounds Related to Methionine during In Vitro Incubation with Rumen Microorganisms

Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruc...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.751-754
Hauptverfasser:	Digenis, G.A., Amos, H.E., Mitchell, G.E., Swintosky, J.V., Yang, K., Schelling, G.T., Parish, R.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Chromatography, Gas Drug Stability effect of rumen microbial amino acid deamination Fermentation Hydroxybutyrates - metabolism Hydroxymethionine derivatives-synthesis Hydroxymethionine derivatives—synthesis, tested for resistance to in vitro destruction by rumen microorganisms in vitro incubation with rumen microorganisms Methionine - metabolism Methionine substitutes-ruminant nutrition Methionine substitutes—ruminant nutrition, stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms Nutrition Nutrition, ruminant—stability of nonnitrogenous compounds compared to methionine, in vitro incubation with rumen microorganisms, effect of rumen microbial amino acid deamination Rumen - microbiology ruminant-stability of nonnitrogenous compounds compared to methionine stability of nonnitrogenous compounds compared to methionine Sulfhydryl Compounds - metabolism tested for resistance to in vitro destruction by rumen microorganisms
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Zusammenfassung:	Four new a-hydroxy derivatives related to methionine were prepared and tested for resistance to in vitro destruction by rumen microorganisms. 3-Hydroxydihydro-2(3H)-thiophenone was rapidly degraded by the microorganisms while its benzoate ester, 3-benzoyloxydihydro-2(3H)-thiophenone, escaped destruction as indicated by specific GLC analysis for the compounds. Two esters, methyl γ-methylmercapto-α-hydroxybutyrate and phenyl γ-methylmercapto-α-hydroxybutyrate, were found to be extensively destroyed upon incubation with rumen microorganisms.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600630521