Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia
Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabol...
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| Veröffentlicht in: | Circulation research 1959-07, Vol.7 (4), p.666-672 |
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| container_end_page | 672 |
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| container_title | Circulation research |
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| creator | Guzman, Santiago V Deleon, Antonio C West, James W Bellet, Samuel |
| description | Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect. |
| doi_str_mv | 10.1161/01.RES.7.4.666 |
| format | Article |
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This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.7.4.666</identifier><identifier>PMID: 13663221</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Acidosis ; Epinephrine - pharmacology ; Heart ; Heart Block ; Hyperkalemia ; Isoproterenol ; Norepinephrine - pharmacology ; Old Medline ; Potassium - blood ; Sympathomimetics</subject><ispartof>Circulation research, 1959-07, Vol.7 (4), p.666-672</ispartof><rights>1959 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4131-b23389f37dd7bc890898dd4d7abd543d12a1fb565b1361cca3316c9763c4d33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13663221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guzman, Santiago V</creatorcontrib><creatorcontrib>Deleon, Antonio C</creatorcontrib><creatorcontrib>West, James W</creatorcontrib><creatorcontrib>Bellet, Samuel</creatorcontrib><title>Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect.</description><subject>Acidosis</subject><subject>Epinephrine - pharmacology</subject><subject>Heart</subject><subject>Heart Block</subject><subject>Hyperkalemia</subject><subject>Isoproterenol</subject><subject>Norepinephrine - pharmacology</subject><subject>Old Medline</subject><subject>Potassium - blood</subject><subject>Sympathomimetics</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkUFv1DAQhS0EotvClSPyiRMJntiJk-OyDd1KFUgUcbUce8KGdeJgJyr9C_xqDLsSHDyj0XzzpPdMyCtgOUAF7xjkn9v7XOYir6rqCdlAWYhMlBKekg1jrMkk5-yCXMb4nTEQvGiekwvgVcWLAjbk104HO2hD275Hs0Tqe3ob_Rz8ggEn797Sjz7gPEw4H0KqVE-Wtv_Nw0R3fpwdLki32Ve6Rx0W-t55c6TXa0K-0fbnjGEYcVq0o1szWB-H-Fdo_5g2R-1wHPQL8qzXLuLLc78i9x_aL7t9dvfp5na3vcuMAA5ZV3BeNz2X1srO1A2rm9paYaXubCm4hUJD35VV2SWXYIzmHCrTyIobYTm_Im9OqsnijxXjosYhGnROT-jXqOqCSwasTGB-Ak3wMQbs1Zw86PCogKk_2SsGKmWvpBIqZZ8OXp-V125E-w8_h50AcQIevEvpxqNbHzCoA2q3HFT6LMYZFBk0ZcNkmrL00tlvHWaQPQ</recordid><startdate>195907</startdate><enddate>195907</enddate><creator>Guzman, Santiago V</creator><creator>Deleon, Antonio C</creator><creator>West, James W</creator><creator>Bellet, Samuel</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195907</creationdate><title>Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia</title><author>Guzman, Santiago V ; Deleon, Antonio C ; West, James W ; Bellet, Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4131-b23389f37dd7bc890898dd4d7abd543d12a1fb565b1361cca3316c9763c4d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Acidosis</topic><topic>Epinephrine - pharmacology</topic><topic>Heart</topic><topic>Heart Block</topic><topic>Hyperkalemia</topic><topic>Isoproterenol</topic><topic>Norepinephrine - pharmacology</topic><topic>Old Medline</topic><topic>Potassium - blood</topic><topic>Sympathomimetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guzman, Santiago V</creatorcontrib><creatorcontrib>Deleon, Antonio C</creatorcontrib><creatorcontrib>West, James W</creatorcontrib><creatorcontrib>Bellet, Samuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guzman, Santiago V</au><au>Deleon, Antonio C</au><au>West, James W</au><au>Bellet, Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1959-07</date><risdate>1959</risdate><volume>7</volume><issue>4</issue><spage>666</spage><epage>672</epage><pages>666-672</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>13663221</pmid><doi>10.1161/01.RES.7.4.666</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7330 |
| ispartof | Circulation research, 1959-07, Vol.7 (4), p.666-672 |
| issn | 0009-7330 1524-4571 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Acidosis Epinephrine - pharmacology Heart Heart Block Hyperkalemia Isoproterenol Norepinephrine - pharmacology Old Medline Potassium - blood Sympathomimetics |
| title | Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia |
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