Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia

Cardiac Effects of Isoproterenol, Norepinephrine and Epinephrine in Complete A-V Heart Block During Experimental Acidosis and Hyperkalemia

Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabol...

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Veröffentlicht in:Circulation research 1959-07, Vol.7 (4), p.666-672
Hauptverfasser: Guzman, Santiago V, Deleon, Antonio C, West, James W, Bellet, Samuel
Format: Artikel
Sprache:eng
Schlagworte:
Acidosis
Epinephrine - pharmacology
Heart
Heart Block
Hyperkalemia
Isoproterenol
Norepinephrine - pharmacology
Old Medline
Potassium - blood
Sympathomimetics
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Zusammenfassung:Acidosis was found to diminish the effectiveness of various sympathomimetic amines (isoproterenol, norepinephrine, and epinephrine) in increasing the idioventricular rate in dogs with experimentally induced complete A-V heart block. This diminution was correlated with the degree of acidosis (metabolic and respiratory). Hyperkalemia without significant pH change had no such effect.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.7.4.666