Local Vascular Effects of Alkalosis in the Dog Gracilis Muscle

Local Vascular Effects of Alkalosis in the Dog Gracilis Muscle

Summary Experiments were completed in isolated, constant flow perfused, dog gracilis muscles to determine effects of local intra-arterial (IA) infusion of several alkalis on muscle vascular resistance. Stepwise increases in pH from approximately 7.44-7.60 with NaOH, Na2CO3, or NaHCO3 did not alter r...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1974-05, Vol.146 (1), p.50-55
1. Verfasser: Emerson, Thomas E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bicarbonates - pharmacology
Blood
Blood Pressure
Carbonates - pharmacology
Dogs
Female
Hydrogen-Ion Concentration
Male
Muscles - blood supply
Regional Blood Flow
Sodium Hydroxide - pharmacology
Vascular Resistance
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Zusammenfassung:Summary Experiments were completed in isolated, constant flow perfused, dog gracilis muscles to determine effects of local intra-arterial (IA) infusion of several alkalis on muscle vascular resistance. Stepwise increases in pH from approximately 7.44-7.60 with NaOH, Na2CO3, or NaHCO3 did not alter resistance. Extreme increases in pH were associated with marked increases in vascular resistance, excepting NaHCO3 which caused no change in resistance. The technical assistance of D. B. McKeag and S. Underwood is gratefully acknowledged.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-146-38041