Effects of Dimethyl Sulfoxide and Trimethylphosphine Oxide on Percutaneous Absorption of Corticosteroids in the Rat
Dimethyl sulfoxide and trimethylphosphine oxide facilitate absorption of a polar steroid (hydrocortisone sodium succinate) through the rat skin. Neither agent significantly increases the rate at which a highly lipid-soluble steroid (cortisone acetate) can penetrate rat skin.
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.793-794 |
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| container_end_page | 794 |
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| container_issue | 5 |
| container_start_page | 793 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 63 |
| creator | Cramer, M.B. Cates, L.A. |
| description | Dimethyl sulfoxide and trimethylphosphine oxide facilitate absorption of a polar steroid (hydrocortisone sodium succinate) through the rat skin. Neither agent significantly increases the rate at which a highly lipid-soluble steroid (cortisone acetate) can penetrate rat skin. |
| doi_str_mv | 10.1002/jps.2600630533 |
| format | Article |
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Pharm. Sci</addtitle><description>Dimethyl sulfoxide and trimethylphosphine oxide facilitate absorption of a polar steroid (hydrocortisone sodium succinate) through the rat skin. Neither agent significantly increases the rate at which a highly lipid-soluble steroid (cortisone acetate) can penetrate rat skin.</description><subject>Absorption</subject><subject>Absorption, percutaneous—effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption, rat</subject><subject>Adrenal Glands - drug effects</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Corticosteroids (hydrocortisone sodium succinate and cortisone acetate)</subject><subject>Corticosteroids (hydrocortisone sodium succinate and cortisone acetate), percutaneous absorption—effects of dimethyl sulfoxide and trimethylphosphine oxide, rat</subject><subject>Cortisone - metabolism</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Dimethyl sulfoxide-effects on percutaneous absorption of corticosteroids</subject><subject>Dimethyl sulfoxide—effects on percutaneous absorption of corticosteroids, rat</subject><subject>Hydrocortisone - metabolism</subject><subject>Male</subject><subject>Organ Size</subject><subject>percutaneous absorption-effects of dimethyl sulfoxide and trimethylphosphine oxide</subject><subject>percutaneous-effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption</subject><subject>Phosphines - pharmacology</subject><subject>rat</subject><subject>Rats</subject><subject>Skin Absorption - drug effects</subject><subject>Thymus Gland - drug effects</subject><subject>Time Factors</subject><subject>Trimethylphosphine oxide-effects on percutaneous absorption of corticosteroids</subject><subject>Trimethylphosphine oxide—effects on percutaneous absorption of corticosteroids, rat</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKkvhyg3JJ25ZHDuOk2O1LS3tihZaVImL5ThjrUs2Tu0Euv-egayKOCAutmbmmye_Z0Je52yZM8bf3Q1pyUvGSsGkEE_IIpecZSXL1VOyQIBnQhb1c_IipTuGGJPygBwUlcBCLUg6cQ7smGhw9NhvYdzsOno9dS48-Bao6Vt6E_f9YRPSsPE90Mvfw9DTK4h2Gk0PYUr0qEkhDqPHPqqtQhy9DWmEGHybqO_puAH62YwvyTNnugSv9vch-fL-5GZ1lq0vTz-sjtaZLbgSGZRGMiFKWbNCCaxMofCQeVOj24aLhjleqZyXIGxd2dbYsqpY65xqbGVBHJK3s-4Qw_0EadRbnyx03fxeXXEUZ6pAcDmDNoaUIjg9oGcTdzpn-lfKGlPWf1LGhTd75anZQvuI72PFeT3Pf_gOdv9R0-dX139pZ_Oux-geHndN_KZLJZTUtx9P9fri_Oz208VXfYx8NfOAUX73EHWyHnoLrY_4s7oN_l82fgJ-x6yT</recordid><startdate>197405</startdate><enddate>197405</enddate><creator>Cramer, M.B.</creator><creator>Cates, L.A.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197405</creationdate><title>Effects of Dimethyl Sulfoxide and Trimethylphosphine Oxide on Percutaneous Absorption of Corticosteroids in the Rat</title><author>Cramer, M.B. ; Cates, L.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4273-e6a50336590473e6aa476aa51b9063b23b0f287126e3c98cdac6880dff7bc8ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Absorption</topic><topic>Absorption, percutaneous—effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption, rat</topic><topic>Adrenal Glands - drug effects</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Corticosteroids (hydrocortisone sodium succinate and cortisone acetate)</topic><topic>Corticosteroids (hydrocortisone sodium succinate and cortisone acetate), percutaneous absorption—effects of dimethyl sulfoxide and trimethylphosphine oxide, rat</topic><topic>Cortisone - metabolism</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Dimethyl sulfoxide-effects on percutaneous absorption of corticosteroids</topic><topic>Dimethyl sulfoxide—effects on percutaneous absorption of corticosteroids, rat</topic><topic>Hydrocortisone - metabolism</topic><topic>Male</topic><topic>Organ Size</topic><topic>percutaneous absorption-effects of dimethyl sulfoxide and trimethylphosphine oxide</topic><topic>percutaneous-effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption</topic><topic>Phosphines - pharmacology</topic><topic>rat</topic><topic>Rats</topic><topic>Skin Absorption - drug effects</topic><topic>Thymus Gland - drug effects</topic><topic>Time Factors</topic><topic>Trimethylphosphine oxide-effects on percutaneous absorption of corticosteroids</topic><topic>Trimethylphosphine oxide—effects on percutaneous absorption of corticosteroids, rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cramer, M.B.</creatorcontrib><creatorcontrib>Cates, L.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cramer, M.B.</au><au>Cates, L.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Dimethyl Sulfoxide and Trimethylphosphine Oxide on Percutaneous Absorption of Corticosteroids in the Rat</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1974-05, Vol.63 (5), p.793-794 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82365074 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Absorption Absorption, percutaneous—effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption, rat Adrenal Glands - drug effects Analysis of Variance Animals Body Weight - drug effects Corticosteroids (hydrocortisone sodium succinate and cortisone acetate) Corticosteroids (hydrocortisone sodium succinate and cortisone acetate), percutaneous absorption—effects of dimethyl sulfoxide and trimethylphosphine oxide, rat Cortisone - metabolism Dimethyl Sulfoxide - pharmacology Dimethyl sulfoxide-effects on percutaneous absorption of corticosteroids Dimethyl sulfoxide—effects on percutaneous absorption of corticosteroids, rat Hydrocortisone - metabolism Male Organ Size percutaneous absorption-effects of dimethyl sulfoxide and trimethylphosphine oxide percutaneous-effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption Phosphines - pharmacology rat Rats Skin Absorption - drug effects Thymus Gland - drug effects Time Factors Trimethylphosphine oxide-effects on percutaneous absorption of corticosteroids Trimethylphosphine oxide—effects on percutaneous absorption of corticosteroids, rat |
| title | Effects of Dimethyl Sulfoxide and Trimethylphosphine Oxide on Percutaneous Absorption of Corticosteroids in the Rat |
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