Effects of Dimethyl Sulfoxide and Trimethylphosphine Oxide on Percutaneous Absorption of Corticosteroids in the Rat

Dimethyl sulfoxide and trimethylphosphine oxide facilitate absorption of a polar steroid (hydrocortisone sodium succinate) through the rat skin. Neither agent significantly increases the rate at which a highly lipid-soluble steroid (cortisone acetate) can penetrate rat skin.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1974-05, Vol.63 (5), p.793-794
Hauptverfasser:	Cramer, M.B., Cates, L.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Absorption, percutaneous—effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption, rat Adrenal Glands - drug effects Analysis of Variance Animals Body Weight - drug effects Corticosteroids (hydrocortisone sodium succinate and cortisone acetate) Corticosteroids (hydrocortisone sodium succinate and cortisone acetate), percutaneous absorption—effects of dimethyl sulfoxide and trimethylphosphine oxide, rat Cortisone - metabolism Dimethyl Sulfoxide - pharmacology Dimethyl sulfoxide-effects on percutaneous absorption of corticosteroids Dimethyl sulfoxide—effects on percutaneous absorption of corticosteroids, rat Hydrocortisone - metabolism Male Organ Size percutaneous absorption-effects of dimethyl sulfoxide and trimethylphosphine oxide percutaneous-effects of dimethyl sulfoxide and trimethylphosphine oxide on corticosteroid absorption Phosphines - pharmacology rat Rats Skin Absorption - drug effects Thymus Gland - drug effects Time Factors Trimethylphosphine oxide-effects on percutaneous absorption of corticosteroids Trimethylphosphine oxide—effects on percutaneous absorption of corticosteroids, rat
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Dimethyl sulfoxide and trimethylphosphine oxide facilitate absorption of a polar steroid (hydrocortisone sodium succinate) through the rat skin. Neither agent significantly increases the rate at which a highly lipid-soluble steroid (cortisone acetate) can penetrate rat skin.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600630533