Serum Globulins in Experimental Nephritis. Effect of Conditioning Factors.

Summary 1. Experimental glomerulonephritis following administration of antirabbit kidney duck serum was induced in normal and preconditioned rabbits. 2. Significant alterations in serum globulins were recorded only in preconditioned animals. a) Rabbits preconditioned with 0.9% saline-drinking water developed clinical symptoms of chronic glomerulonephritis and showed significant increase of alpha-2 serum globulin fraction. b) Animals preconditioned by uninephrectomy showed severe nephritis-nephrosis lesions associated with significant increase of serum globulin fraction situated between alpha-2 and beta globulin (alpha-3 globulin) in the moving boundary electrophoretic patterns.