B-Cell Alloantigens Determined by the H-2 Linked Ir Region Are Associated with Mixed Lymphocyte Culture Stimulation

Cell surface antigens, controlled by genes located in the Ir region of the murine major histocompatibility complex, are shown serologically to be expressed preferentially on bone marrow-derived lymphocytes. These antigens may play a major role as stimulators in mixed lymphocyte cultures.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1974-02, Vol.183 (4126), p.757-759
Hauptverfasser:	Lozner, Eugene C., Sachs, David H., Shearer, Gene M., Terry, William D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antiserum B lymphocytes B-Lymphocytes - immunology Chromosome Mapping Congenic strains Crossing Over, Genetic Epithelial cells Genetic Linkage Genetic loci Graft vs Host Reaction Histocompatibility Histocompatibility Antigens Immune Sera Isoantigens Lymphocyte Culture Test, Mixed Lymphocytes Mice Mice, Inbred Strains Mixed lymphocyte culture test Models, Biological Recombination, Genetic Skin Transplantation Surface antigens T lymphocytes Transplantation, Homologous
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Beschreibung
Zusammenfassung:	Cell surface antigens, controlled by genes located in the Ir region of the murine major histocompatibility complex, are shown serologically to be expressed preferentially on bone marrow-derived lymphocytes. These antigens may play a major role as stimulators in mixed lymphocyte cultures.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.183.4126.757