CNS Depressant Effects of Schiff Bases Derived from 4, 6-dichloro-5-pyrimidinecarboxaldehydes and Substituted Anilines

Several Schiff bases were prepared by the reaction of 4, 6-dichloro-5-pyrimidinecarboxaldehydes with substituted anilines. When the aniline was substituted at the ortho-position by a mercapto group, cyclization to the corresponding benzothiazoline resulted. A representative number of the new compoun...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-03, Vol.63 (3), p.449-451
Hauptverfasser:	Santilli, Arthur A., Kim, Dong Han, Fieber, Richard A., Wanser, Stephen V.
Format:	Artikel
Sprache:	eng
Schlagworte:	4, 6-Dichloro-5-pyrimidinecarboxaldehydes—reacted with substituted anilines to form Schiff bases, CNS depressant activity 6-dichloro-5-pyrimidinecarboxaldehydes and substituted anilines 6-dichloro-5-pyrimidinecarboxaldehydes to form Schiff bases 6-Dichloro-5-pyrimidinecarboxaldehydes-reacted with substituted anilines to form Schiff bases Aldehydes - pharmacology Aniline Compounds - chemical synthesis Aniline Compounds - pharmacology Anilines Anilines, substituted—reacted with 4, 6-dichloro-5-pyrimidinecarboxaldehydes to form Schiff bases, CNS depressant activity Animals CNS depressant activity CNS depressant activity-Schiff bases formed from 4 CNS depressant activity—Schiff bases formed from 4, 6-dichloro-5-pyrimidinecarboxaldehydes and substituted anilines Depression, Chemical Hypnotics and Sedatives - pharmacology Mice Motor Activity - drug effects Pyrimidines - chemical synthesis Pyrimidines - pharmacology Respiration - drug effects Schiff Bases Schiff bases-prepared from 4 Schiff bases—prepared from 4, 6-dichloro-5-pyrimidinecarboxaldehydes and substituted anilines, CNS depressant activity substituted-reacted with 4
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