CNS Depressant Effects of Schiff Bases Derived from 4, 6-dichloro-5-pyrimidinecarboxaldehydes and Substituted Anilines

Several Schiff bases were prepared by the reaction of 4, 6-dichloro-5-pyrimidinecarboxaldehydes with substituted anilines. When the aniline was substituted at the ortho-position by a mercapto group, cyclization to the corresponding benzothiazoline resulted. A representative number of the new compounds showed CNS depressant activity in mice at doses ranging from 12.7 to 400 mg/kg ip.