Effect of Dietary Choline and Ethanol on Hepatic Triglycerides and Activity of Hepatic Ethanol Oxidizing Enzymes in Rats

Effect of Dietary Choline and Ethanol on Hepatic Triglycerides and Activity of Hepatic Ethanol Oxidizing Enzymes in Rats

Summary Female rats were maintained for 21 days on a liquid diet with and without choline supplementation. Ethanol was given to half of the rats as an isocaloric substitution for dietary sucrose. Choline supplementation inhibited the accumulation of hepatic triglycerides and was required for maximum...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1974-03, Vol.145 (3), p.1061-1064
Hauptverfasser: Rifenbrick, David H., Narrod, Stuart A., Myerson, Ralph M., Scorpio, Ralph M.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol Oxidoreductases - metabolism
Animals
Choline - pharmacology
Dietary Fats
Ethanol - pharmacology
Female
Liver - metabolism
Microsomes, Liver - enzymology
Rats
Triglycerides - metabolism
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Zusammenfassung:Summary Female rats were maintained for 21 days on a liquid diet with and without choline supplementation. Ethanol was given to half of the rats as an isocaloric substitution for dietary sucrose. Choline supplementation inhibited the accumulation of hepatic triglycerides and was required for maximum stimulation of the hepatic microsomal ethanol oxidizing system (MEOS) activity. Increase in hepatic alcohol dehydrogenase (ADH) activity did not occur.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-145-37953