New Type Sedative and Soporific Drug

New Type Sedative and Soporific Drug

Trimethoxybenzoyl-glycine-diethylamide induced in dogs and cats normal sleep without preceding ataxia. A five- to ten-fold increase of the soporific dose resulted in restlessness and disorientation instead of sleep. In man, oral doses of 500 to 1500 mg caused sedation or drowsiness, or both, in half...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1958-12, Vol.128 (3338), p.1570-1571
Hauptverfasser: Cronheim, Georg, Gourzis, James T., Toekes, I. M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Ataxia
Cats
Dogs
Dosage
Eggs
Electroencephalography
Embryos
Hemoglobins
Humans
Hypnotics and Sedatives
Inbred strains
Male
Old Medline
Polysaccharides
Sleep
Sleep Stages
Viruses
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Beschreibung
Zusammenfassung:Trimethoxybenzoyl-glycine-diethylamide induced in dogs and cats normal sleep without preceding ataxia. A five- to ten-fold increase of the soporific dose resulted in restlessness and disorientation instead of sleep. In man, oral doses of 500 to 1500 mg caused sedation or drowsiness, or both, in half the cases. No spindling or drug-induced artifacts were found in electroencephalographic recordings.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.128.3338.1570