Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the en...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1974-04, Vol.184 (4135), p.482-484
Hauptverfasser:	Koerker, Donna J., Ruch, Willy, Chideckel, Elliott, Palmer, Jerry, Goodner, Charles J., Ensinck, John, Gale, Charles C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - pharmacology Blood Glucose Depression, Chemical Electrodes Fasting Glucagon - blood Glucagon - metabolism Growth Hormone - metabolism Growth Hormone-Releasing Hormone - antagonists & inhibitors Growth hormones Hormones Hypoglycemia Hypothalamus Insulin Insulin - blood Insulin - metabolism Insulin Secretion Nonesterified fatty acids Pancreas - drug effects Pancreas - metabolism Papio Peptides - pharmacology Pituitary Gland - drug effects Pituitary Gland - metabolism Secretion Stomach Vagotomy
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Beschreibung
Zusammenfassung:	Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.184.4135.482