‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents

THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1959-02, Vol.183 (4658), p.399-400
Hauptverfasser:	BARDOS, THOMAS J., PAPANASTASSIOU, ZINON B., SEGALOFF, ALBERT, AMBRUS, JULIAN L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents Carbamates Esters Humanities and Social Sciences Humans letter multidisciplinary Neoplasms Old Medline Science Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	400
container_issue	4658
container_start_page	399
container_title	Nature (London)
container_volume	183
creator	BARDOS, THOMAS J. PAPANASTASSIOU, ZINON B. SEGALOFF, ALBERT AMBRUS, JULIAN L.
description	THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking several consecutive and/or alternative metabolic pathways, while others vigorously object to this thesis, from practical considerations or disappointing experiences.
doi_str_mv	10.1038/183399a0
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_82293953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>82293953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-db25149b1e45c5815ad7013a1af444e48763d77cd92626b27db937e70443f11b3</originalsourceid><addsrcrecordid>eNplkM1OwkAUhSdGI4gmPoHpysBidP7aacOK4G9CcCGum2l7C8VpB2faGHY8hr4eT2IJGBcubs7ifvmScxC6pOSGEh7e0pDzKFLkCHWpkAEWQSiPUZcQFmIS8qCDzpxbEkJ8KsUp6lAecCZ50EV6u_m6a5T2RlWt5qYqXO22m--hN9Lva-1NcT8pHO5DvVhrqIqyyMxgtTCuPWsGOFU2UaWqwQ095U3h03sFW4DzTL4zFnjWlKax3mgOVe3O0UmutIOLQ_bQ28P9bPyEJy-Pz-PRBKec-jXOEuZTESUUhJ_6IfVVJgnliqpcCAEilAHPpEyziAUsSJjMkohLkEQInlOa8B663ntX1nw04Oq4LFwKWqsKTOPikLGIRz5vwf4eTK1xzkIer2xRKruOKYl3y8a_y7bo1cHZJCVkf-BhyhYY7AHXvqo52HjZNq_anv9lP6CCgRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>82293953</pqid></control><display><type>article</type><title>‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><creator>BARDOS, THOMAS J. ; PAPANASTASSIOU, ZINON B. ; SEGALOFF, ALBERT ; AMBRUS, JULIAN L.</creator><creatorcontrib>BARDOS, THOMAS J. ; PAPANASTASSIOU, ZINON B. ; SEGALOFF, ALBERT ; AMBRUS, JULIAN L.</creatorcontrib><description>THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking several consecutive and/or alternative metabolic pathways, while others vigorously object to this thesis, from practical considerations or disappointing experiences.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/183399a0</identifier><identifier>PMID: 13632736</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antineoplastic Agents ; Carbamates ; Esters ; Humanities and Social Sciences ; Humans ; letter ; multidisciplinary ; Neoplasms ; Old Medline ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1959-02, Vol.183 (4658), p.399-400</ispartof><rights>Springer Nature Limited 1959</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-db25149b1e45c5815ad7013a1af444e48763d77cd92626b27db937e70443f11b3</citedby><cites>FETCH-LOGICAL-c315t-db25149b1e45c5815ad7013a1af444e48763d77cd92626b27db937e70443f11b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/183399a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/183399a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13632736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARDOS, THOMAS J.</creatorcontrib><creatorcontrib>PAPANASTASSIOU, ZINON B.</creatorcontrib><creatorcontrib>SEGALOFF, ALBERT</creatorcontrib><creatorcontrib>AMBRUS, JULIAN L.</creatorcontrib><title>‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking several consecutive and/or alternative metabolic pathways, while others vigorously object to this thesis, from practical considerations or disappointing experiences.</description><subject>Antineoplastic Agents</subject><subject>Carbamates</subject><subject>Esters</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Neoplasms</subject><subject>Old Medline</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1959</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkM1OwkAUhSdGI4gmPoHpysBidP7aacOK4G9CcCGum2l7C8VpB2faGHY8hr4eT2IJGBcubs7ifvmScxC6pOSGEh7e0pDzKFLkCHWpkAEWQSiPUZcQFmIS8qCDzpxbEkJ8KsUp6lAecCZ50EV6u_m6a5T2RlWt5qYqXO22m--hN9Lva-1NcT8pHO5DvVhrqIqyyMxgtTCuPWsGOFU2UaWqwQ095U3h03sFW4DzTL4zFnjWlKax3mgOVe3O0UmutIOLQ_bQ28P9bPyEJy-Pz-PRBKec-jXOEuZTESUUhJ_6IfVVJgnliqpcCAEilAHPpEyziAUsSJjMkohLkEQInlOa8B663ntX1nw04Oq4LFwKWqsKTOPikLGIRz5vwf4eTK1xzkIer2xRKruOKYl3y8a_y7bo1cHZJCVkf-BhyhYY7AHXvqo52HjZNq_anv9lP6CCgRA</recordid><startdate>19590207</startdate><enddate>19590207</enddate><creator>BARDOS, THOMAS J.</creator><creator>PAPANASTASSIOU, ZINON B.</creator><creator>SEGALOFF, ALBERT</creator><creator>AMBRUS, JULIAN L.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19590207</creationdate><title>‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents</title><author>BARDOS, THOMAS J. ; PAPANASTASSIOU, ZINON B. ; SEGALOFF, ALBERT ; AMBRUS, JULIAN L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-db25149b1e45c5815ad7013a1af444e48763d77cd92626b27db937e70443f11b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1959</creationdate><topic>Antineoplastic Agents</topic><topic>Carbamates</topic><topic>Esters</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Neoplasms</topic><topic>Old Medline</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARDOS, THOMAS J.</creatorcontrib><creatorcontrib>PAPANASTASSIOU, ZINON B.</creatorcontrib><creatorcontrib>SEGALOFF, ALBERT</creatorcontrib><creatorcontrib>AMBRUS, JULIAN L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARDOS, THOMAS J.</au><au>PAPANASTASSIOU, ZINON B.</au><au>SEGALOFF, ALBERT</au><au>AMBRUS, JULIAN L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1959-02-07</date><risdate>1959</risdate><volume>183</volume><issue>4658</issue><spage>399</spage><epage>400</epage><pages>399-400</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking several consecutive and/or alternative metabolic pathways, while others vigorously object to this thesis, from practical considerations or disappointing experiences.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13632736</pmid><doi>10.1038/183399a0</doi><tpages>2</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0028-0836
ispartof	Nature (London), 1959-02, Vol.183 (4658), p.399-400
issn	0028-0836 1476-4687
language	eng
recordid	cdi_proquest_miscellaneous_82293953
source	MEDLINE; Nature; Springer Nature - Complete Springer Journals
subjects	Antineoplastic Agents Carbamates Esters Humanities and Social Sciences Humans letter multidisciplinary Neoplasms Old Medline Science Science (multidisciplinary)
title	‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T12%3A21%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%E2%80%98Dual%20Antagonists%E2%80%99;%20Alkyl%20N-(bis-(ethylenimido)phosphoro)-carbamates;%20a%20New%20Series%20of%20Anti-Tumour%20Agents&rft.jtitle=Nature%20(London)&rft.au=BARDOS,%20THOMAS%20J.&rft.date=1959-02-07&rft.volume=183&rft.issue=4658&rft.spage=399&rft.epage=400&rft.pages=399-400&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/183399a0&rft_dat=%3Cproquest_cross%3E82293953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=82293953&rft_id=info:pmid/13632736&rfr_iscdi=true