‘Dual Antagonists’; Alkyl N-(bis-(ethylenimido)phosphoro)-carbamates; a New Series of Anti-Tumour Agents

THE concept of combination chemotherapy in the treatment of neoplastic diseases has been receiving considerable attention during the past few years. Some see the only theoretically possible solution to the problem of cancer chemotherapy in the simultaneous use of several synergistic drugs blocking several consecutive and/or alternative metabolic pathways, while others vigorously object to this thesis, from practical considerations or disappointing experiences.