Diuretic Activity of Chlorothiazide Derivatives

CHLOROTHIAZIDE (6-chloro-7-sulphamyl-1,2,4-benzothiadiazine-1,1-dioxide) is not only a very active diuretic drug, but it can also relieve high blood pressure in many patients. This compound has an inhibitory action on carbonic anhydrase, like N-acetylamino-sulphamyl-thiadiazole, and in addition it causes a diuresis not unlike that observed with organic mercurial compounds 1,2 , resulting in increased excretion of sodium salts and of water. It seemed interesting to us to analyse the structural conditions necessary for a diuretic activity and, especially, what influence can be attributed to the sulphamyl-group.