Effect of Cobalt Chloride on the Content of Lipid and Glycolytic Intermediates in Rabbit Liver and Heart

Effect of Cobalt Chloride on the Content of Lipid and Glycolytic Intermediates in Rabbit Liver and Heart

The effects of cobalt chloride on various parameters of lipid and carbohydrate metabolism were examined in rabbit heart and liver. Hyperglycemia induced by cobalt chloride acted to elevate the glucose content of the heart, and also elevated the glucose, G-6-P and F-6-P content of the liver in starve...

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Veröffentlicht in:Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 1973/12/28, Vol.28(5), pp.456-462
Hauptverfasser: Ohyama, Kayoko, Morita, Hiroyuki, Hasegawa, Takeshi, Koike, Shigeo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cobalt - pharmacology
Glycogen - metabolism
Glycolysis - drug effects
Infusions, Parenteral
Lipid Metabolism
Liver - metabolism
Male
Myocardium - metabolism
Rabbits
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container_issue 5
container_start_page 456
container_title Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
container_volume 28
creator Ohyama, Kayoko
Morita, Hiroyuki
Hasegawa, Takeshi
Koike, Shigeo
description The effects of cobalt chloride on various parameters of lipid and carbohydrate metabolism were examined in rabbit heart and liver. Hyperglycemia induced by cobalt chloride acted to elevate the glucose content of the heart, and also elevated the glucose, G-6-P and F-6-P content of the liver in starved rabbits. Marked elevation of plasma triglyceride levels in cobalt treated rabbits was accompanied by the accumulation of triglyceride in the liver; the triglyceride content of the heart was increased but not significantly, so. Cobalt acted to reduce the elevated concentration of plasma FFA induced by starvation. Plasma FFA might be utilized similarly in both cobalt-treated and starved rabbits to elevate the triglyceride content of the liver and the blood β-hydroxybutyrate concentration.
doi_str_mv 10.1265/jjh.28.456
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subjects Animals
Cobalt - pharmacology
Glycogen - metabolism
Glycolysis - drug effects
Infusions, Parenteral
Lipid Metabolism
Liver - metabolism
Male
Myocardium - metabolism
Rabbits
title Effect of Cobalt Chloride on the Content of Lipid and Glycolytic Intermediates in Rabbit Liver and Heart
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