Effect of Cobalt Chloride on the Content of Lipid and Glycolytic Intermediates in Rabbit Liver and Heart

The effects of cobalt chloride on various parameters of lipid and carbohydrate metabolism were examined in rabbit heart and liver. Hyperglycemia induced by cobalt chloride acted to elevate the glucose content of the heart, and also elevated the glucose, G-6-P and F-6-P content of the liver in starved rabbits. Marked elevation of plasma triglyceride levels in cobalt treated rabbits was accompanied by the accumulation of triglyceride in the liver; the triglyceride content of the heart was increased but not significantly, so. Cobalt acted to reduce the elevated concentration of plasma FFA induced by starvation. Plasma FFA might be utilized similarly in both cobalt-treated and starved rabbits to elevate the triglyceride content of the liver and the blood β-hydroxybutyrate concentration.