General Rhodium-Catalyzed Cyanation of Aryl and Alkenyl Boronic Acids

General Rhodium-Catalyzed Cyanation of Aryl and Alkenyl Boronic Acids

Give me a cyanide: N‐cyano‐N‐phenyl‐p‐methylbenzenesulfonamide as a cyanation reagent allows the synthesis of aryl(alkenyl) nitriles in good yield under mild conditions (see scheme; cod=cycloocta‐1,5‐diene). Combination of the procedure with the direct borylation of arenes and hydroboration of alkyn...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2011-01, Vol.50 (2), p.519-522
Hauptverfasser: Anbarasan, Pazhamalai, Neumann, Helfried, Beller, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
benzonitriles
boronic acids
cyanation
homogeneous catalysis
Rhodium
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Zusammenfassung:Give me a cyanide: N‐cyano‐N‐phenyl‐p‐methylbenzenesulfonamide as a cyanation reagent allows the synthesis of aryl(alkenyl) nitriles in good yield under mild conditions (see scheme; cod=cycloocta‐1,5‐diene). Combination of the procedure with the direct borylation of arenes and hydroboration of alkynes leads to the straightforward synthesis of various nitriles.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201006044