A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. DISCOVERY AND ISOLATION
A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against...
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| Veröffentlicht in: | Journal of antibiotics 1973/08/25, Vol.26(8), pp.463-465 |
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| container_end_page | 465 |
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| container_issue | 8 |
| container_start_page | 463 |
| container_title | Journal of antibiotics |
| container_volume | 26 |
| creator | HAMILL, ROBERT L. HOEHN, MARVIN M. |
| description | A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against Candida species, Saccharomyces pastorianus, plant disease fungi, and Trypanosoma species. It has an LD50 (subcutaneous) of 185 mg/kg in mice. |
| doi_str_mv | 10.7164/antibiotics.26.463 |
| format | Article |
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DISCOVERY AND ISOLATION</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>HAMILL, ROBERT L. ; HOEHN, MARVIN M.</creator><creatorcontrib>HAMILL, ROBERT L. ; HOEHN, MARVIN M.</creatorcontrib><description>A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against Candida species, Saccharomyces pastorianus, plant disease fungi, and Trypanosoma species. It has an LD50 (subcutaneous) of 185 mg/kg in mice.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.26.463</identifier><identifier>PMID: 4792069</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Acetylation ; Adenine - analysis ; Aminoglycosides - analysis ; Aminoglycosides - isolation & purification ; Aminoglycosides - pharmacology ; Antifungal Agents - analysis ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Candida - drug effects ; Chromatography, Paper ; Crystallization ; Microbial Sensitivity Tests ; Molecular Weight ; Saccharomyces - drug effects ; Spectrophotometry, Infrared ; Streptomyces - analysis ; Trypanosoma - drug effects</subject><ispartof>The Journal of Antibiotics, 1973/08/25, Vol.26(8), pp.463-465</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4792069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAMILL, ROBERT L.</creatorcontrib><creatorcontrib>HOEHN, MARVIN M.</creatorcontrib><title>A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. 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It has an LD50 (subcutaneous) of 185 mg/kg in mice.</description><subject>Acetylation</subject><subject>Adenine - analysis</subject><subject>Aminoglycosides - analysis</subject><subject>Aminoglycosides - isolation & purification</subject><subject>Aminoglycosides - pharmacology</subject><subject>Antifungal Agents - analysis</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Candida - drug effects</subject><subject>Chromatography, Paper</subject><subject>Crystallization</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Weight</subject><subject>Saccharomyces - drug effects</subject><subject>Spectrophotometry, Infrared</subject><subject>Streptomyces - analysis</subject><subject>Trypanosoma - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKw0AUhgdRaq2-gCBk5crUuWUuyzGmNVjSTYrLYWY60ZT0YiZd-PYGG4qbc374Pw6cD4B7BKccMfpsdl1t631XuzDFbEoZuQBjJASKEWXyEowhxCgWAsNrcBPCBkLCCRcjMKJcYsjkGCRKIpo8RSoqso9IvWZFXmRxuixKlfdxHqmizGerYq4Wf_ElX5Z5eguuKtMEfzfsCVjNsjJ9ixfLeZ6qRbwhCetiStbWVJQTmzDikEfCSC6srKyhDEKHKgKp565yibQEV7CyxFK4ps4J3gcyAY-nu4d2_330odPbOjjfNGbn98egBcYMMUJ78GEAj3br1_rQ1lvT_ujhz75_P_Wb0JlPf-5N28trvP5nEkkmNGZ6GL3UM-W-TKv9jvwC1mFsMQ</recordid><startdate>1973</startdate><enddate>1973</enddate><creator>HAMILL, ROBERT L.</creator><creator>HOEHN, MARVIN M.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1973</creationdate><title>A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC</title><author>HAMILL, ROBERT L. ; HOEHN, MARVIN M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j356t-43dbaf473b563c1e18a978b9fba4600c1f304e7cfc59b32f0fb3b40d4cc87b403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Acetylation</topic><topic>Adenine - analysis</topic><topic>Aminoglycosides - analysis</topic><topic>Aminoglycosides - isolation & purification</topic><topic>Aminoglycosides - pharmacology</topic><topic>Antifungal Agents - analysis</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Candida - drug effects</topic><topic>Chromatography, Paper</topic><topic>Crystallization</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Weight</topic><topic>Saccharomyces - drug effects</topic><topic>Spectrophotometry, Infrared</topic><topic>Streptomyces - analysis</topic><topic>Trypanosoma - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAMILL, ROBERT L.</creatorcontrib><creatorcontrib>HOEHN, MARVIN M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAMILL, ROBERT L.</au><au>HOEHN, MARVIN M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. DISCOVERY AND ISOLATION</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1973</date><risdate>1973</risdate><volume>26</volume><issue>8</issue><spage>463</spage><epage>465</epage><pages>463-465</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against Candida species, Saccharomyces pastorianus, plant disease fungi, and Trypanosoma species. It has an LD50 (subcutaneous) of 185 mg/kg in mice.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>4792069</pmid><doi>10.7164/antibiotics.26.463</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1973/08/25, Vol.26(8), pp.463-465 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82261634 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Acetylation Adenine - analysis Aminoglycosides - analysis Aminoglycosides - isolation & purification Aminoglycosides - pharmacology Antifungal Agents - analysis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Candida - drug effects Chromatography, Paper Crystallization Microbial Sensitivity Tests Molecular Weight Saccharomyces - drug effects Spectrophotometry, Infrared Streptomyces - analysis Trypanosoma - drug effects |
| title | A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. DISCOVERY AND ISOLATION |
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