A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. DISCOVERY AND ISOLATION

A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC: I. DISCOVERY AND ISOLATION

A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against...

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Veröffentlicht in:Journal of antibiotics 1973/08/25, Vol.26(8), pp.463-465
Hauptverfasser: HAMILL, ROBERT L., HOEHN, MARVIN M.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
Adenine - analysis
Aminoglycosides - analysis
Aminoglycosides - isolation & purification
Aminoglycosides - pharmacology
Antifungal Agents - analysis
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Candida - drug effects
Chromatography, Paper
Crystallization
Microbial Sensitivity Tests
Molecular Weight
Saccharomyces - drug effects
Spectrophotometry, Infrared
Streptomyces - analysis
Trypanosoma - drug effects
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Beschreibung
Zusammenfassung:A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against Candida species, Saccharomyces pastorianus, plant disease fungi, and Trypanosoma species. It has an LD50 (subcutaneous) of 185 mg/kg in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.26.463