Temperature-dependence of Dinitrocresol Stimulation of Aerobic and Anaerobic Lactate Production in Ascites Tumor Cells
Summary Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, al...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1958-11, Vol.99 (2), p.415-418 |
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| container_end_page | 418 |
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| container_issue | 2 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 99 |
| creator | Clowes, G. H. A. Walters, C. P. Keltch, A. K. |
| description | Summary
Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, although the absolute rate of lactate production diminishes. Aerobic lactate production is stimulated to a greater degree than anaerobic and the former exceeds the latter under certain conditions. The implications and possible mechanisms of these phenomena are discussed. |
| doi_str_mv | 10.3181/00379727-99-24368 |
| format | Article |
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Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, although the absolute rate of lactate production diminishes. Aerobic lactate production is stimulated to a greater degree than anaerobic and the former exceeds the latter under certain conditions. The implications and possible mechanisms of these phenomena are discussed.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-99-24368</identifier><identifier>PMID: 13601888</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Ascites ; Carcinoma, Ehrlich Tumor ; Cresols - pharmacology ; Dinitrocresols ; Encephalomyelitis - diagnosis ; Lactates - metabolism ; Lactic Acid ; Neoplasms - metabolism ; Old Medline ; Temperature</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1958-11, Vol.99 (2), p.415-418</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-6303bdcf7729b343de337547b62efc4d0c17ff0254342ff5eee1d3a56c9c083f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13601888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clowes, G. H. A.</creatorcontrib><creatorcontrib>Walters, C. P.</creatorcontrib><creatorcontrib>Keltch, A. K.</creatorcontrib><title>Temperature-dependence of Dinitrocresol Stimulation of Aerobic and Anaerobic Lactate Production in Ascites Tumor Cells</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, although the absolute rate of lactate production diminishes. Aerobic lactate production is stimulated to a greater degree than anaerobic and the former exceeds the latter under certain conditions. The implications and possible mechanisms of these phenomena are discussed.</description><subject>Animals</subject><subject>Ascites</subject><subject>Carcinoma, Ehrlich Tumor</subject><subject>Cresols - pharmacology</subject><subject>Dinitrocresols</subject><subject>Encephalomyelitis - diagnosis</subject><subject>Lactates - metabolism</subject><subject>Lactic Acid</subject><subject>Neoplasms - metabolism</subject><subject>Old Medline</subject><subject>Temperature</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1958</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS1ERZfCB-CCfOKWYnviOD6ulvJHWolKLGfLscfIVRIvtoPUb99sdxE3TqPR-72nmUfIO85ugff8I2OgtBKq0boRLXT9C7LhEmQDndYvyeakNyfgmrwu5YExLpXoXpFrDh3jfd9vyJ8DTkfMti4ZG49HnD3ODmkK9FOcY83JZSxppD9qnJbR1pjmk7jFnIboqJ093c72su2tq7Yivc_JL-6ZjTPdFhcrFnpYppTpDsexvCFXwY4F317mDfn5-e6w-9rsv3_5ttvuGwfQ16YDBoN3QSmhB2jBI4CSrRo6gcG1njmuQmBCttCKECQicg9Wdk471kOAG_LhnHvM6feCpZopFrdeYGdMSzG9EFJ2WqwgP4Mup1IyBnPMcbL50XBmTmWbv2Ubrc1z2avn_SV8GSb0_xyXdlfg9gwU-wvNQ1ryvD77n8Qn8a6JcQ</recordid><startdate>195811</startdate><enddate>195811</enddate><creator>Clowes, G. H. A.</creator><creator>Walters, C. P.</creator><creator>Keltch, A. K.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195811</creationdate><title>Temperature-dependence of Dinitrocresol Stimulation of Aerobic and Anaerobic Lactate Production in Ascites Tumor Cells</title><author>Clowes, G. H. A. ; Walters, C. P. ; Keltch, A. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-6303bdcf7729b343de337547b62efc4d0c17ff0254342ff5eee1d3a56c9c083f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1958</creationdate><topic>Animals</topic><topic>Ascites</topic><topic>Carcinoma, Ehrlich Tumor</topic><topic>Cresols - pharmacology</topic><topic>Dinitrocresols</topic><topic>Encephalomyelitis - diagnosis</topic><topic>Lactates - metabolism</topic><topic>Lactic Acid</topic><topic>Neoplasms - metabolism</topic><topic>Old Medline</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clowes, G. H. A.</creatorcontrib><creatorcontrib>Walters, C. P.</creatorcontrib><creatorcontrib>Keltch, A. K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clowes, G. H. A.</au><au>Walters, C. P.</au><au>Keltch, A. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-dependence of Dinitrocresol Stimulation of Aerobic and Anaerobic Lactate Production in Ascites Tumor Cells</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1958-11</date><risdate>1958</risdate><volume>99</volume><issue>2</issue><spage>415</spage><epage>418</epage><pages>415-418</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, although the absolute rate of lactate production diminishes. Aerobic lactate production is stimulated to a greater degree than anaerobic and the former exceeds the latter under certain conditions. The implications and possible mechanisms of these phenomena are discussed.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13601888</pmid><doi>10.3181/00379727-99-24368</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1958-11, Vol.99 (2), p.415-418 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Ascites Carcinoma, Ehrlich Tumor Cresols - pharmacology Dinitrocresols Encephalomyelitis - diagnosis Lactates - metabolism Lactic Acid Neoplasms - metabolism Old Medline Temperature |
| title | Temperature-dependence of Dinitrocresol Stimulation of Aerobic and Anaerobic Lactate Production in Ascites Tumor Cells |
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