The antenatal diagnosis of genetic disease

In the past five years, rapid advances in the antenatal diagnosis of genetic disease have been made. In our center, an Amniotic Fluid Study Group has been formed for research in this area. In addition, an Antenatal Genetic Clinic with a multidisciplinary approach has been established. Our experience in monitoring 73 genetically high-risk patients by amniocentesis is reported. Bloody taps and failed crdtures were significantly reduced with the use of preamniocentesis ultrasound placental localization. Four spontaneous abortions followed amniocentesis. Regionalization and a team approach to this complex area are recommended.