Aortopulmonary Septal Defect Due to Staphylococcal Endocarditis

The first known case of aortopulmonary septal defect due to infective endocarditis is reported. A 21-year-old man with aortic insufficiency due to active staphylococcal endocarditis required aortic valve replacement. A week later a faint continuous murmur was first heard, which became very loud the next day. An aortopulmonary septal defect was confirmed by cardiac catheterization. Fifty-six hours after the continuous murmur was first heard, he developed florid pulmonary edema and died. Aortopulmonary septal defect due to staphylococcal endocarditis was confirmed at postmortem examination. This case illustrates the malignant nature of an aortopulmonary septal defect due to staphylococcal endocarditis.