Lithium Prophylaxis in Recurrent Affective Illness

The authors report on two recent two-year studies that attempted to determine the effectiveness of lithium carbonate in treating recurrent affective illness. In study I, 205 bipolar (manic-depressive) patients were randomly assigned to lithium or placebo; in study 2, 44 bipolar and 78 unipolar (depr...

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Veröffentlicht in:	The American journal of psychiatry 1974-02, Vol.131 (2), p.198-203
Hauptverfasser:	PRIEN, ROBERT F, KLETT, C. JAMES, CAFFEY, EUGENE M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Bipolar Disorder - diagnosis Bipolar Disorder - drug therapy Bipolar Disorder - prevention & control Clinical Trials as Topic Depression - diagnosis Depression - drug therapy Depression - prevention & control Drug Evaluation Female Hospitalization Humans Imipramine - therapeutic use Lithium - therapeutic use Male Middle Aged Patient Dropouts Placebos Psychiatric Status Rating Scales Recurrence Remission, Spontaneous
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Beschreibung
Zusammenfassung:	The authors report on two recent two-year studies that attempted to determine the effectiveness of lithium carbonate in treating recurrent affective illness. In study I, 205 bipolar (manic-depressive) patients were randomly assigned to lithium or placebo; in study 2, 44 bipolar and 78 unipolar (depressive) patients were randomly assigned lithium, imipramine, or placebo. The results showed lithium to be effective in treating both manic and depressive episodes and imipramine to be effective in treating depressive episodes. The findings emphasize the importance of considering the patient's previous course of illness in selecting a program of maintenance treatment.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.131.2.198