Prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with acute lymphoblastic leukaemia (ALL) treated without cranial irradiation: Results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group study 58881

Abstract Aim of the study To evaluate the prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with ALL enrolled from 1989 to 1996 in the EORTC 58881 trial. Patients and methods Patients (2025) were categorised according to initial central nervous system (CNS) st...

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Veröffentlicht in:	European journal of cancer (1990) 2011-01, Vol.47 (2), p.239-247
Hauptverfasser:	Sirvent, Nicolas, Suciu, Stefan, Rialland, Xavier, Millot, Frédéric, Benoit, Yves, Plantaz, Dominique, Ferster, Alice, Robert, Alain, Lutz, Patrick, Nelken, Brigitte, Plouvier, Emmanuel, Norton, Lucilia, Bertrand, Yves, Otten, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukaemia Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Central nervous system Central Nervous System Neoplasms - cerebrospinal fluid Central Nervous System Neoplasms - drug therapy Central Nervous System Neoplasms - mortality Cerebrospinal Fluid - cytology Chemotherapy Child Child, Preschool Childhood Female Hematology, Oncology and Palliative Medicine Humans Infant Kaplan-Meier Estimate Leukocytes Male Medical sciences Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - cerebrospinal fluid Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Prognosis Radiotherapy Recurrence Retrospective Studies Stem Cell Transplantation - methods
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Zusammenfassung:	Abstract Aim of the study To evaluate the prognostic significance of the initial cerebro-spinal fluid (CSF) involvement of children with ALL enrolled from 1989 to 1996 in the EORTC 58881 trial. Patients and methods Patients (2025) were categorised according to initial central nervous system (CNS) status: CNS-1 (CNS negative, n = 1866), CNS-2 (
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2010.10.019