Synthesis of 2-Oxazolones and α-Aminoketones via Palladium-Catalyzed Reaction of β,β-Dibromoenamides

β,β-Dibromoenamides show two different interesting reactivities based on the choice of R group under the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki−Miyaura C−C coupling and an intramolecular C−O coupling.

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Veröffentlicht in:	Organic letters 2011-01, Vol.13 (1), p.106-109
Hauptverfasser:	Chai, David I, Hoffmeister, Laura, Lautens, Mark
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Sprache:	eng
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creator	Chai, David I Hoffmeister, Laura Lautens, Mark
description	β,β-Dibromoenamides show two different interesting reactivities based on the choice of R group under the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki−Miyaura C−C coupling and an intramolecular C−O coupling.
doi_str_mv	10.1021/ol102634c
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title	Synthesis of 2-Oxazolones and α-Aminoketones via Palladium-Catalyzed Reaction of β,β-Dibromoenamides
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