Synthesis of 2-Oxazolones and α-Aminoketones via Palladium-Catalyzed Reaction of β,β-Dibromoenamides

Synthesis of 2-Oxazolones and α-Aminoketones via Palladium-Catalyzed Reaction of β,β-Dibromoenamides

β,β-Dibromoenamides show two different interesting reactivities based on the choice of R group under the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki−Miyaura C−C coupling and an intramolecular C−O coupling.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-01, Vol.13 (1), p.106-109
Hauptverfasser: Chai, David I, Hoffmeister, Laura, Lautens, Mark
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:β,β-Dibromoenamides show two different interesting reactivities based on the choice of R group under the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki−Miyaura C−C coupling and an intramolecular C−O coupling.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102634c