Deiodination of Thyroxine and Other Iodinated Compounds During Desalting by Electrodialysis.

Conclusions 1) Use of electrolytic desalter to remove inorganic ions from solution, results in removal of iodine from aromatic linkage, including thyroxine, triiodothyronine, diiodotyrosine and several of the fatty acid side-chain analogues of thyroxine. 2) This prevents use of apparatus for preparation of salt-free solutions in thyroid studies. The procedure might be useful in preparation of various dehalogenated derivatives where the parent compounds are readily available.