O-methylation, the Principal Route of Metabolism of Epinephrine in Man

O-methylation, the Principal Route of Metabolism of Epinephrine in Man

Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transfe...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1958-09, Vol.128 (3324), p.593-594
Hauptverfasser: LaBrosse, Elwood H., Axelrod, Julius, Kety, Seymour S.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Catechol O-Methyltransferase
Enzymes
Epinephrine - metabolism
Humans
Kidneys
Male
Metabolism
Methylation
Nephrons
Old Medline
Oxidases
Papillae
Radioactive decay
Transferases
Tubular structures
Urine
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Beschreibung
Zusammenfassung:Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.128.3324.593