Proliferation of the reticuloendothelial system and phagocytosis

The phagocytosis and the cellular and organ distribution of polystyrene latex particles were studied in normal rabbits and rabbits treated with complete Freund's adjuvant. The size of the particles, the amount injected and the number of cells capable of phagocytosis were of importance in determining the clearance of the blood. The clearance curves were analyzed in terms of an equilibrium between phagocytosis and re-entry of particles into the circulation. Despite extensive proliferation of the RES produced by Freund's adjuvant the general nature of the clearance from the circulation was not changed. The implications of these findings in the interpretations of clearance of the blood and the process of phagocytosis were discussed.