Inhibition of glycolytic metabolism and sleep-waking states in cats

In cats, injections of 2-deoxy-D-glucose, a glucose antimetabolite, produces dose-dependent increases of slow wave sleep and decreases of REM sleep. Accordingly, variations of glycolytic metabolism may participate in the control of sleep-waking behavior.

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1973, Vol.1 (1), p.117-119
Hauptverfasser:	Panksepp, Jaak, Jalowiec, John E., Zolovick, A.J., Stern, Warren C., Morgane, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-deoxy-D-glucose Animals Blood Glucose Cats Dose-Response Relationship, Drug Electrodes, Implanted Glucose - pharmacology Glycolysis - drug effects Glycolytic metabolism REM Sleep Sleep - drug effects Sleep, REM - drug effects Time Factors Wakefulness - drug effects
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Beschreibung
Zusammenfassung:	In cats, injections of 2-deoxy-D-glucose, a glucose antimetabolite, produces dose-dependent increases of slow wave sleep and decreases of REM sleep. Accordingly, variations of glycolytic metabolism may participate in the control of sleep-waking behavior.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(73)90065-8