Mechanism of inhibition of catalase by 3-amino-1,2,4-triazole

Mechanism of inhibition of catalase by 3-amino-1,2,4-triazole

Injection of 3-amino-1,2,4-triazole (AT) reduces the catalase activity of six solid tissues in the same order as does the implantation of a tumor. In vitro, dilute AT, in combination with a widely distributed heat-stable factor (HSF), reduces the activity of crystalline catalase. Alcoholtreated HSF...

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Veröffentlicht in:Archives of biochemistry and biophysics 1958-07, Vol.76 (1), p.32-44
Hauptverfasser: Feinstein, Robert N., Berliner, Sara, Green, Frank O.
Format: Artikel
Sprache:eng
Schlagworte:
Amitrole
Azoles - pharmacology
Catalase - antagonists & inhibitors
Old Medline
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Zusammenfassung:Injection of 3-amino-1,2,4-triazole (AT) reduces the catalase activity of six solid tissues in the same order as does the implantation of a tumor. In vitro, dilute AT, in combination with a widely distributed heat-stable factor (HSF), reduces the activity of crystalline catalase. Alcoholtreated HSF prevents catalase inhibition by an otherwise active HSF-AT system.
ISSN:0003-9861
1096-0384
DOI:10.1016/0003-9861(58)90116-4