A Consideration of a Mechanism of Augmentation of Peripheral Vascular Resistance in Hypertension : Presence of F-actin Filament in Renal Arterioles and Electrolytes Contents in Arterial Wall in Hypertensive Rat (Goldblatt Type)

It was electronmicroscopically shown that thick and thin filaments similar to myosin aggregates and F-action constituting arterial natural actomyosin were present even in renal arteriolar or capillary endothelium. Amounts of Ca2+, Mg2+ and Na+/K+ contained in arterial wall appeared to be higher in renovascular hypertensive rats than those in normotensive rats, although amounts of these electrolytes in skeletal muscle were not different between them. Since it has been clarified that free ion concentrations of these electrolytes have influence on the contractile activity of arterial natural actomyosin, the role of these electrolytes in arterial wall for the induction of hypertension was discussed on the basis of a hypothesis that an augmentation in the active contractility of peripheral arterioles may play an etiological role for the essential hypertension.