Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

The fact that CDC caused a greater depletion of ATPi suggests that bile acids have additional effects which further decrease ATPi. [...]we used the deoxy-glucose (DOG)/iodoacetamide (IAA) model which inhibits intracellular glycolytic metabolism. [...]we provided evidence that ATPi depletion is crucial in the toxic inhibitory effect of CDC on the ion transporters.