Mediation of Progestational Action of Amphenone by the Rabbit Adrenal
Summary Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational change...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1958-05, Vol.98 (1), p.157-160 |
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| container_issue | 1 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 98 |
| creator | Tullner, William W. |
| description | Summary
Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational changes in the rabbit endometrium. It was suggested that amphenone exerts its progestational effect on the rabbit uterus by inhibition of specific enzyme systems in the adrenocortical biosynthetic pathway resulting in excess progestogen secretion. |
| doi_str_mv | 10.3181/00379727-98-23973 |
| format | Article |
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Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational changes in the rabbit endometrium. It was suggested that amphenone exerts its progestational effect on the rabbit uterus by inhibition of specific enzyme systems in the adrenocortical biosynthetic pathway resulting in excess progestogen secretion.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-98-23973</identifier><identifier>PMID: 13554575</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adrenal Cortex - physiology ; Animals ; Female ; Humans ; Negotiating ; Old Medline ; Propiophenones - pharmacology ; Rabbits ; Uterus - drug effects</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1958-05, Vol.98 (1), p.157-160</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-7b10e1fc5f99241a70d972bca3e939dc0e4e95a191341aa5930f99da3cff89d93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13554575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tullner, William W.</creatorcontrib><title>Mediation of Progestational Action of Amphenone by the Rabbit Adrenal</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational changes in the rabbit endometrium. It was suggested that amphenone exerts its progestational effect on the rabbit uterus by inhibition of specific enzyme systems in the adrenocortical biosynthetic pathway resulting in excess progestogen secretion.</description><subject>Adrenal Cortex - physiology</subject><subject>Animals</subject><subject>Female</subject><subject>Humans</subject><subject>Negotiating</subject><subject>Old Medline</subject><subject>Propiophenones - pharmacology</subject><subject>Rabbits</subject><subject>Uterus - drug effects</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1958</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwA7ignLil2HFcZ49RVR5SEQjB2XKcTZsqiYudHPrvcR-IG6fVar4d7Qwht4xOOcvYA6VcgkxkDFmccJD8jIyZ4CLmM4BzMt7r8R4YkSvvN5QyIZPZJRkxLkQqpBiTxSuWte5r20W2it6dXaHvD7tuotz8Cnm7XWNnO4yKXdSvMfrQRVH3UV46DOQ1uah04_HmNCfk63HxOX-Ol29PL_N8GRvOsz6WBaPIKiMqgCRlWtIyfFcYzRE4lIZiiiA0A8aDqgVwGshSc1NVGZTAJ-T-6Lt19nsIn6q29gabRndoB6-yJCSUaRZAdgSNs947rNTW1a12O8Wo2nenfrtTkKlDd-Hm7mQ-FC2WfxensgIwPQJer1Bt7OBCdP-P4w_WG3ab</recordid><startdate>195805</startdate><enddate>195805</enddate><creator>Tullner, William W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195805</creationdate><title>Mediation of Progestational Action of Amphenone by the Rabbit Adrenal</title><author>Tullner, William W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-7b10e1fc5f99241a70d972bca3e939dc0e4e95a191341aa5930f99da3cff89d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1958</creationdate><topic>Adrenal Cortex - physiology</topic><topic>Animals</topic><topic>Female</topic><topic>Humans</topic><topic>Negotiating</topic><topic>Old Medline</topic><topic>Propiophenones - pharmacology</topic><topic>Rabbits</topic><topic>Uterus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tullner, William W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tullner, William W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediation of Progestational Action of Amphenone by the Rabbit Adrenal</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1958-05</date><risdate>1958</risdate><volume>98</volume><issue>1</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational changes in the rabbit endometrium. It was suggested that amphenone exerts its progestational effect on the rabbit uterus by inhibition of specific enzyme systems in the adrenocortical biosynthetic pathway resulting in excess progestogen secretion.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13554575</pmid><doi>10.3181/00379727-98-23973</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1958-05, Vol.98 (1), p.157-160 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82157748 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Cortex - physiology Animals Female Humans Negotiating Old Medline Propiophenones - pharmacology Rabbits Uterus - drug effects |
| title | Mediation of Progestational Action of Amphenone by the Rabbit Adrenal |
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