Mediation of Progestational Action of Amphenone by the Rabbit Adrenal

Summary Progestational proliferation of the rabbit endometrium in response to amphenone has been shown to be dependent on the adrenals. The progestational effect of amphenone was prevented by adrenalectomy as well as by cortisone treatment. Large doses of ACTH failed to produce progestational changes in the rabbit endometrium. It was suggested that amphenone exerts its progestational effect on the rabbit uterus by inhibition of specific enzyme systems in the adrenocortical biosynthetic pathway resulting in excess progestogen secretion.