Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils

Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them agai...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2010-12, Vol.435 (1), p.316-319
Hauptverfasser: Yurinskaya, M. M., Evgen’ev, M. B., Antonova, O. Yu, Vinokurov, M. G.
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container_title Doklady. Biochemistry and biophysics
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creator Yurinskaya, M. M.
Evgen’ev, M. B.
Antonova, O. Yu
Vinokurov, M. G.
description Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them against lipopolysaccharide and lipoteichoic acid.
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subjects Animals
Bacteria
Bacterial infections
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Cellular biology
Escherichia coli - chemistry
Heat shock proteins
HSP70 Heat-Shock Proteins - pharmacology
Humans
Immune system
Leukocytes
Life Sciences
Lipopolysaccharides - immunology
Neutrophil Activation - drug effects
Neutrophil Activation - immunology
Neutrophils - drug effects
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - microbiology
Reactive Oxygen Species - metabolism
Sepsis
Staphylococcus aureus - chemistry
Teichoic Acids - immunology
title Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils
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