Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils
Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them agai...
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Veröffentlicht in: | Doklady. Biochemistry and biophysics 2010-12, Vol.435 (1), p.316-319 |
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container_title | Doklady. Biochemistry and biophysics |
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creator | Yurinskaya, M. M. Evgen’ev, M. B. Antonova, O. Yu Vinokurov, M. G. |
description | Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them against lipopolysaccharide and lipoteichoic acid. |
doi_str_mv | 10.1134/S1607672910060098 |
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M. ; Evgen’ev, M. B. ; Antonova, O. Yu ; Vinokurov, M. G.</creator><creatorcontrib>Yurinskaya, M. M. ; Evgen’ev, M. B. ; Antonova, O. Yu ; Vinokurov, M. G.</creatorcontrib><description>Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them against lipopolysaccharide and lipoteichoic acid.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672910060098</identifier><identifier>PMID: 21184302</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Animals ; Bacteria ; Bacterial infections ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biophysics and Molecular Biology ; Cellular biology ; Escherichia coli - chemistry ; Heat shock proteins ; HSP70 Heat-Shock Proteins - pharmacology ; Humans ; Immune system ; Leukocytes ; Life Sciences ; Lipopolysaccharides - immunology ; Neutrophil Activation - drug effects ; Neutrophil Activation - immunology ; Neutrophils - drug effects ; Neutrophils - immunology ; Neutrophils - metabolism ; Neutrophils - microbiology ; Reactive Oxygen Species - metabolism ; Sepsis ; Staphylococcus aureus - chemistry ; Teichoic Acids - immunology</subject><ispartof>Doklady. 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In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them against lipopolysaccharide and lipoteichoic acid.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><pmid>21184302</pmid><doi>10.1134/S1607672910060098</doi><tpages>4</tpages></addata></record> |
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subjects | Animals Bacteria Bacterial infections Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Cellular biology Escherichia coli - chemistry Heat shock proteins HSP70 Heat-Shock Proteins - pharmacology Humans Immune system Leukocytes Life Sciences Lipopolysaccharides - immunology Neutrophil Activation - drug effects Neutrophil Activation - immunology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology Reactive Oxygen Species - metabolism Sepsis Staphylococcus aureus - chemistry Teichoic Acids - immunology |
title | Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils |
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