Exogenous heat shock protein HSP70 suppresses bacterial pathogen-induced activation of human neutrophils

Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them agai...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2010-12, Vol.435 (1), p.316-319
Hauptverfasser:	Yurinskaya, M. M., Evgen’ev, M. B., Antonova, O. Yu, Vinokurov, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial infections Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Cellular biology Escherichia coli - chemistry Heat shock proteins HSP70 Heat-Shock Proteins - pharmacology Humans Immune system Leukocytes Life Sciences Lipopolysaccharides - immunology Neutrophil Activation - drug effects Neutrophil Activation - immunology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology Reactive Oxygen Species - metabolism Sepsis Staphylococcus aureus - chemistry Teichoic Acids - immunology
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Beschreibung
Zusammenfassung:	Neutrophils play the key role in the inflammatory response of humans and animals developing during bacterial infection. In this study with human neutrophils, which play the key role in sepsis development, it is shown that the 70 kDa exogenous heat shock protein (HSP70) effectively protects them against lipopolysaccharide and lipoteichoic acid.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672910060098