Clinical Evaluation of Pharmacotherapy for Peptic Ulcer with Antipepsin Agents by Double Blind Technique: Multicenter Clinical Study

In an attempt to examine the clinical effectiveness of pharmacotherapy for peptic ulcer through the standardized formula, clinical investigations were performed in a total of 255 cases of peptic ulcer at 13 medical institutes with the double blind technique. The antipepsin agents, namely degraded carrageenin was used as an active drug and aluminum sucrose sulfate as an active placebo, and lactose as an inactive placebo. The results indicated that both antipepsin agents are effective for the treatment of peptic ulcer without noticeable side effects. The therapeutic effect was more clearly shown on the following findings or symptoms, viz., x-ray and endoscopic findings, hypochodralgia, vomiting, epigastralgia, belching, meteorism, sense of distention, anorexia, retching, sense of gastric discomfort, abnormal fermentation, fecal occult blood reaction, tenderness, heartburn, constipation, and nausea. It was also disclosed that the global judgement of effectiveness had beenn made based chiefly on the x-ray and gastroscopic findings, and then on the outcome of such subjective symptoms as retching, vomiting, nausea, and anorexia. Problems involved in the clinical evaluation of pharmacotherapy for peptic ulcer by the double blind technique were also discussed.